Research comparison
Tesamorelin vs Sermorelin
Side-by-side comparison of research status, mechanisms, pharmacokinetics, and administration routes.
Tesamorelin is a stabilized synthetic GHRH analog FDA-approved for reduction of excess abdominal fat in HIV-infected adults with lipodystrophy. It stimulates pulsatile GH secretion while preserving natural feedback regulation. Research demonstrates significant visceral adipose tissue reduction, improved lipid profiles, and cognitive benefits, making it a key study compound for metabolic dysfunction.
Research Status
FDA Approved
Half-Life
~26 minutes
Molecular Formula
—
Molecular Weight
—
CAS Number
218949-48-5
Research Categories
Growth Hormone Axis, Fat Loss & Metabolic
Routes of Administration
Sermorelin is a synthetic analog of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It stimulates the pituitary to produce and secrete growth hormone in a pulsatile, physiologic manner. FDA-approved for GH deficiency in children, it is extensively researched in adults for body composition, sleep quality, and age-related GH decline.
Research Status
FDA Approved
Half-Life
10–20 minutes
Molecular Formula
C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight
3357.88 Da
CAS Number
86168-78-7
Research Categories
Growth Hormone Axis, Anti-Aging & Longevity
Routes of Administration
Full mechanism comparison
Mechanism of action, pharmacokinetics, and research findings comparison available on the Researcher plan.
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