Peptide Database

ET-1 · Big endothelin-1

Endothelin-1 (ET-1) is a 21-amino-acid vasoconstrictor peptide produced primarily by vascular endothelial cells. It is the most potent endogenous vasoconstrictor known, acting through ETA and ETB receptors on vascular smooth muscle and endothelium. Elevated ET-1 is implicated in pulmonary arterial hypertension, heart failure, and renal disease — driving the development of endothelin receptor antagonists (bosentan, ambrisentan, macitentan) as clinical drugs.