BNP
ApprovedBrain Natriuretic Peptide · Nesiritide
BNP (B-type/brain natriuretic peptide) is a 32-amino-acid hormone secreted by ventricular cardiomyocytes in response to wall stress and volume overload. Clinically, it is the primary biomarker for heart failure diagnosis and prognosis. Recombinant BNP (nesiritide/Natrecor) was approved for acute decompensated heart failure, producing vasodilation and natriuresis. Research into modified natriuretic peptides continues for heart failure therapy.