Peptide Database

NPY

Neuropeptide Y (NPY) is a 36-amino-acid peptide and the most abundant neuropeptide in the mammalian CNS, acting through Y1–Y6 receptors. It is a potent orexigenic signal (stimulating appetite and fat storage), anxiolytic agent, vasoconstrictor, and regulator of circadian rhythms. Paradoxically, peripheral NPY promotes fat accumulation while central NPY drives food intake — making it a complex but high-priority metabolic research target.

ADH · Antidiuretic Hormone

Vasopressin (AVP) is a 9-amino-acid neuropeptide produced in the hypothalamus and released by the posterior pituitary. It regulates water reabsorption via V2 receptors in renal collecting ducts and vasoconstriction via V1a receptors in blood vessels. Clinically used for diabetes insipidus, septic shock vasodilation, GI hemorrhage, and cardiac arrest. Extensive research also examines its roles in social bonding, memory, and stress responses.

Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide with pleiotropic anti-inflammatory, bronchodilatory, and immunomodulatory effects mediated through VPAC1 and VPAC2 receptors. Research spans pulmonary arterial hypertension (inhaled VIP trials), inflammatory bowel disease, sepsis, Parkinson's disease, and CIRS (chronic inflammatory response syndrome). It suppresses Th1 cytokines and promotes Treg cell function.