Peptide Database

BK · Kallidin precursor fragment

Bradykinin is a 9-amino-acid vasoactive peptide of the kinin-kallikrein system. It produces vasodilation, increased vascular permeability, pain, and inflammation by acting on B1 and B2 receptors. ACE inhibitors (a major drug class) lower blood pressure partly by preventing bradykinin degradation. Icatibant, a B2 antagonist, is approved for hereditary angioedema. Research also implicates bradykinin in COVID-19 pathology (bradykinin storm hypothesis).

ET-1 · Big endothelin-1

Endothelin-1 (ET-1) is a 21-amino-acid vasoconstrictor peptide produced primarily by vascular endothelial cells. It is the most potent endogenous vasoconstrictor known, acting through ETA and ETB receptors on vascular smooth muscle and endothelium. Elevated ET-1 is implicated in pulmonary arterial hypertension, heart failure, and renal disease — driving the development of endothelin receptor antagonists (bosentan, ambrisentan, macitentan) as clinical drugs.

Thymosin Beta-4 Fragment · Tβ4 fragment

TB-500 is a synthetic version of the active region of Thymosin Beta-4, a naturally occurring peptide found in virtually all human cells. Research shows it promotes actin polymerization and cell migration, which accelerates wound healing, muscle repair, and vascular growth. It is particularly studied for its ability to reduce inflammation and promote cardiac tissue repair.

C₂₁₂H₃₅₀N₅₆O₇₈S · 4963.44 Da