Peptide Database

Anti-Obesity Drug 9604 · hGH Fragment 177-191

AOD-9604 is a modified fragment of human growth hormone (hGH 177-191) that retains the lipolytic properties of GH without its anabolic or diabetogenic effects. It stimulates lipolysis through β3-adrenergic receptor pathways and inhibits lipogenesis. Phase 3 trials for obesity were conducted; it has since been investigated for osteoarthritis through cartilage repair properties.

HGH Frag 176-191 · Growth Hormone Fragment 176-191

Fragment 176-191 is the C-terminal amino acid sequence 176–191 of human growth hormone, closely related to AOD-9604. It mimics the lipolytic activity of natural GH without binding to the GH receptor, thus avoiding insulin resistance and proliferative effects. Research shows it reduces fat mass in animal models by enhancing fat metabolism and inhibiting new fat formation.

Motilin-related peptide · Growth hormone secretagogue

Ghrelin is a 28-amino-acid acylated peptide hormone primarily produced by gastric X/A-like cells and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). It stimulates GH release, increases appetite and food intake, promotes energy storage, and modulates sleep and mood. Research explores ghrelin axis manipulation for obesity, cachexia, heart failure, and neurodegenerative diseases.