Peptide Database

Motilin-related peptide · Growth hormone secretagogue

Ghrelin is a 28-amino-acid acylated peptide hormone primarily produced by gastric X/A-like cells and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). It stimulates GH release, increases appetite and food intake, promotes energy storage, and modulates sleep and mood. Research explores ghrelin axis manipulation for obesity, cachexia, heart failure, and neurodegenerative diseases.

Growth Hormone-Releasing Hormone · Somatoliberin

GHRH is the endogenous 44-amino-acid hypothalamic peptide that drives the pulsatile secretion of growth hormone from the anterior pituitary. Native GHRH acts through GHRHR, stimulating GH gene transcription and secretion. It has a very short half-life in vivo, making it impractical as a therapeutic — which drove the development of modified analogs like sermorelin, CJC-1295, and tesamorelin. Research into GHRH receptor signaling underpins the entire GH secretagogue drug class.

Growth Hormone-Releasing Peptide 6 · His-DTrp-Ala-Trp-DPhe-Lys-NH₂

GHRP-6 is one of the original synthetic GHRPs, acting as a strong ghrelin receptor agonist. It produces robust GH release accompanied by significant appetite stimulation — a property that makes it both valuable for cachexia research and distinct from cleaner GHRPs like Ipamorelin. Research also shows cytoprotective and cardioprotective properties independent of GH secretion.

C₄₆H₅₆N₁₂O₆ · 873.02 Da

NNC 26-0161

Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. Unlike other GHRPs, it stimulates GH release with high selectivity — producing minimal cortisol, ACTH, or prolactin elevation. It is among the most studied GHRPs for its clean GH pulse profile, making it a preferred research peptide for GH axis studies with reduced side effect concern.

C₃₈H₄₉N₉O₅ · 711.86 Da