Peptide Database

CJC-1295 with DAC · DAC:GRF

CJC-1295 is a modified GHRH analog with a Drug Affinity Complex (DAC) that binds to serum albumin, dramatically extending its half-life compared to native GHRH. It produces sustained elevation of GH and IGF-1 levels over days rather than hours. Research focuses on body composition improvements, muscle growth, and fat loss through prolonged GH axis stimulation.

C₁₅₂H₂₅₂N₄₂O₄₂S · 3647.28 Da

Motilin-related peptide · Growth hormone secretagogue

Ghrelin is a 28-amino-acid acylated peptide hormone primarily produced by gastric X/A-like cells and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). It stimulates GH release, increases appetite and food intake, promotes energy storage, and modulates sleep and mood. Research explores ghrelin axis manipulation for obesity, cachexia, heart failure, and neurodegenerative diseases.

Growth Hormone-Releasing Hormone · Somatoliberin

GHRH is the endogenous 44-amino-acid hypothalamic peptide that drives the pulsatile secretion of growth hormone from the anterior pituitary. Native GHRH acts through GHRHR, stimulating GH gene transcription and secretion. It has a very short half-life in vivo, making it impractical as a therapeutic — which drove the development of modified analogs like sermorelin, CJC-1295, and tesamorelin. Research into GHRH receptor signaling underpins the entire GH secretagogue drug class.

Growth Hormone-Releasing Peptide 6 · His-DTrp-Ala-Trp-DPhe-Lys-NH₂

GHRP-6 is one of the original synthetic GHRPs, acting as a strong ghrelin receptor agonist. It produces robust GH release accompanied by significant appetite stimulation — a property that makes it both valuable for cachexia research and distinct from cleaner GHRPs like Ipamorelin. Research also shows cytoprotective and cardioprotective properties independent of GH secretion.

C₄₆H₅₆N₁₂O₆ · 873.02 Da

Long R3 IGF-1 · Insulin-like Growth Factor 1 Long R3

IGF-1 LR3 is a modified version of Insulin-like Growth Factor-1 with an arginine substitution and 13-amino-acid N-terminal extension, which reduces binding to IGF-binding proteins and extends its half-life. It promotes muscle cell hyperplasia and hypertrophy by activating the PI3K/AKT/mTOR pathway. Research explores its role in muscle wasting, recovery from injury, and anabolic signaling.

Insulin-like Growth Factor 2 · Somatomedin A

IGF-2 is a 67-amino-acid peptide growth factor closely related to IGF-1, primarily active during fetal and neonatal development. In adults, research highlights its potent cognitive effects — IGF-2 administration after training enhances long-term memory consolidation in rodents by a remarkable degree, acting through IGF2R and mannose-6-phosphate receptors in the hippocampus. It has also emerged as a candidate for treating cognitive deficits in aging and neurodegenerative disease.

NNC 26-0161

Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. Unlike other GHRPs, it stimulates GH release with high selectivity — producing minimal cortisol, ACTH, or prolactin elevation. It is among the most studied GHRPs for its clean GH pulse profile, making it a preferred research peptide for GH axis studies with reduced side effect concern.

C₃₈H₄₉N₉O₅ · 711.86 Da

MGF · IGF-1Ec

Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene expressed in response to mechanical loading and muscle damage. Unlike systemic IGF-1, MGF activates satellite cells (muscle stem cells) to proliferate before differentiating — a critical step in muscle repair and growth. Research indicates it plays a distinct, non-overlapping role with systemic IGF-1 in tissue regeneration.

CJC-1295 without DAC · Modified GRF 1-29

Mod GRF 1-29 is a modified version of GHRH(1-29) with four amino acid substitutions that increase stability and half-life without the DAC albumin-binding component. It produces a natural, pulsatile GH release and is commonly paired with GHRPs (like Ipamorelin) for a synergistic GH pulse. Its shorter duration preserves natural pituitary feedback mechanisms.

PEGylated Mechano Growth Factor

PEG-MGF is a PEGylated (polyethylene glycol-modified) form of Mechano Growth Factor, designed to dramatically extend its biological half-life from minutes to days while preserving activity. PEGylation allows systemic delivery and sustained satellite cell activation without the need for local injection. Research shows enhanced muscle hypertrophy signaling compared to unmodified MGF.