Peptide Database

Trappin-2 · SKALP

Elafin is an endogenous serine protease inhibitor (serpin-like) peptide produced by epithelial cells at mucosal surfaces. It inhibits neutrophil elastase and proteinase 3, protecting tissues from excessive inflammatory damage, while also exhibiting direct antimicrobial activity against bacteria and fungi. Research focuses on inflammatory bowel disease, cystic fibrosis, ARDS, and vaginal microbiome modulation, where recombinant elafin is in Phase 2 trials.