Peptide Database

Lys-Pro-Val · α-MSH C-terminal tripeptide

KPV is a tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). It exhibits potent anti-inflammatory effects by inhibiting NF-κB signaling and proinflammatory cytokine production. Research is particularly focused on its potential for inflammatory bowel disease, colitis, and skin inflammation, with studies showing efficacy even when administered orally or topically.