Peptide Database

Beta-Alanyl-N-methyl-L-histidine

Anserine is a methylated dipeptide analog of carnosine found in high concentrations in avian and fish muscle. It shares carnosine's pH-buffering and antioxidant properties but shows superior blood-brain barrier penetration. Research highlights potential for cognitive decline prevention, reduction of amyloid-beta toxicity, and improved exercise performance. It is often studied alongside carnosine for synergistic effects.

Ala-Glu-Asp-Pro · AEDP

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) characterized as a cortex cytoprotective peptide in research from the St. Petersburg Institute. It penetrates the blood-brain barrier and is reported to regulate neuronal gene expression, protect cortical neurons, and improve cognitive function in aging models. It is often studied alongside other peptide bioregulators from the same research group.

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · PNB-0408

Dihexa is a small peptide derived from angiotensin IV that acts as a potent agonist at the HGF/c-Met receptor system, which mediates synaptogenesis — the formation of new synaptic connections. Animal studies suggest it may be several orders of magnitude more potent than BDNF at promoting synapse formation. Research focuses on Alzheimer's disease, cognitive decline, and traumatic brain injury.

HN · mitochondria-derived peptide humanin

Humanin is a 21-amino-acid mitochondria-derived peptide (MDP) encoded within the 16S rRNA gene of mitochondrial DNA. It is cytoprotective against Alzheimer's-related neuronal death, reduces oxidative stress, improves insulin sensitivity, and suppresses apoptosis through multiple pathways (STAT3, IGFBP-3, FPRL1). Circulating humanin levels decline with age, linking it to age-related diseases.

P21 cognitive peptide

P21 is a peptide fragment derived from CNTF (Ciliary Neurotrophic Factor) designed to activate the STAT3 signaling pathway, which promotes neurogenesis and cognitive function. Animal research demonstrates improved spatial memory, increased hippocampal neurogenesis, and enhanced BDNF expression. It is studied as a non-cytokine CNTF functional mimetic without the systemic side effects of full-length CNTF.

EDR peptide · Glu-Asp-Arg

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the St. Petersburg Institute of Bioregulation and Gerontology. It is characterized as a pineal gland cytoprotective peptide that penetrates the blood-brain barrier and acts as a transcription factor, regulating gene expression in neuronal cells. Research suggests neuroprotective, antioxidant, and cognition-preserving effects, particularly in aging and hypoxic conditions.