Peptide Database

Body Protection Compound 157 · PL 14736

BPC-157 is a 15-amino-acid peptide fragment derived from human gastric juice. It is one of the most extensively researched peptides for tissue repair, demonstrating accelerated healing of tendons, ligaments, muscle, bone, and gut lining in animal models. It appears to upregulate growth hormone receptors and promote angiogenesis at injury sites.

C₆₂H₉₈N₁₆O₂₂ · 1419.55 Da

BK · Kallidin precursor fragment

Bradykinin is a 9-amino-acid vasoactive peptide of the kinin-kallikrein system. It produces vasodilation, increased vascular permeability, pain, and inflammation by acting on B1 and B2 receptors. ACE inhibitors (a major drug class) lower blood pressure partly by preventing bradykinin degradation. Icatibant, a B2 antagonist, is approved for hereditary angioedema. Research also implicates bradykinin in COVID-19 pathology (bradykinin storm hypothesis).

Leu-Enkephalin · Met-Enkephalin

Enkephalins are endogenous opioid pentapeptides (Met-enkephalin and Leu-enkephalin) acting as natural ligands for delta and mu opioid receptors. They modulate pain, mood, reward, and immune function. Low-dose naltrexone (LDN) works partly by transiently blocking opioid receptors to upregulate enkephalin production. Methionine enkephalin (met-enkephalin) has shown immune-modulating and anti-tumor properties in research, particularly for HIV and cancer.

GAL

Galanin is a 29-30 amino acid neuropeptide widely distributed throughout the CNS and peripheral nervous system. It modulates memory, mood, pain, seizures, appetite, and sleep via three receptor subtypes (GALR1–3). Research focuses on its roles in Alzheimer's disease (galanin hyperinnervation of cholinergic neurons), depression, epilepsy, and eating behavior. Both agonists and antagonists have therapeutic potential depending on the target condition.

Lys-Pro-Val · α-MSH C-terminal tripeptide

KPV is a tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). It exhibits potent anti-inflammatory effects by inhibiting NF-κB signaling and proinflammatory cytokine production. Research is particularly focused on its potential for inflammatory bowel disease, colitis, and skin inflammation, with studies showing efficacy even when administered orally or topically.

NT · NTS

Neurotensin is a 13-amino-acid neuropeptide found in the brain and GI tract. Centrally, it modulates dopamine circuits, acts as an endogenous antipsychotic-like agent, and is analgesic. Peripherally, it inhibits gastric acid secretion, stimulates pancreatic secretion, and promotes fat absorption. Research explores neurotensin analogs for pain, schizophrenia, Parkinson's disease, and metabolic regulation.

SP · NK1 ligand

Substance P is an 11-amino-acid neuropeptide of the tachykinin family and a primary neurotransmitter of pain signaling in the spinal cord. It binds NK1 receptors to mediate neurogenic inflammation, pain hypersensitivity, and emotional processing. NK1 antagonists have been developed for pain, depression (aprepitant), and nausea. Research also implicates substance P in wound healing, immune activation, and neuroinflammation.

Alpha-Melanocyte-Stimulating Hormone · α-Melanotropin

α-MSH is an endogenous 13-amino-acid peptide derived from POMC (pro-opiomelanocortin). It activates MC1R to stimulate melanin production in skin, MC4R to suppress appetite and regulate energy expenditure, and MC3R/MC1R to exert potent anti-inflammatory effects. It is the parent compound from which many synthetic melanocortin analogs (Melanotan I, II, PT-141, KPV) were derived and remains a cornerstone of melanocortin pharmacology research.