Peptide Database

GnRH · Gonadotropin-Releasing Hormone

Gonadorelin is a synthetic decapeptide identical to endogenous GnRH. When administered in pulsatile fashion it stimulates LH and FSH release from the pituitary, driving gonadal testosterone and estrogen production. Clinically used for diagnosing hypothalamic-pituitary dysfunction, treating hypogonadotropic hypogonadism, and inducing ovulation. Paradoxically, continuous administration causes receptor downregulation and hormonal suppression — the basis of GnRH agonist therapy in prostate cancer.

KP-10 · metastin 45-54

Kisspeptin-10 is the shortest biologically active fragment of the kisspeptin peptide family, which are potent endogenous activators of the hypothalamic GnRH pulse generator. Research demonstrates it stimulates LH and FSH release and has been studied for infertility, hypogonadotropic hypogonadism, and modulating sexual aversion in psychological studies. It represents a key upstream regulator of the reproductive axis.