Peptide Database

Delta Sleep Inducing Peptide · Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

DSIP (Delta Sleep Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep. Research shows it promotes slow-wave sleep, reduces pain sensitivity, normalizes circadian rhythms, lowers cortisol, and exhibits stress-protective effects. It also stimulates LH release and may influence GH pulsatility. Multiple mechanisms of action are proposed; its receptor has not been fully characterized.

Epitalon · Epithalamin

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on the endogenous pineal peptide epithalamin. It is one of the most extensively studied longevity peptides, with Russian research demonstrating telomerase activation, telomere elongation, melatonin normalization, and extended lifespan in animal models. Long-term human studies show reduced all-cause mortality rates and improved biomarkers of aging.

Motilin-related peptide · Growth hormone secretagogue

Ghrelin is a 28-amino-acid acylated peptide hormone primarily produced by gastric X/A-like cells and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). It stimulates GH release, increases appetite and food intake, promotes energy storage, and modulates sleep and mood. Research explores ghrelin axis manipulation for obesity, cachexia, heart failure, and neurodegenerative diseases.

Hypocretin-1 · OXA

Orexin A (Hypocretin-1) is a 33-amino-acid neuropeptide produced exclusively by lateral hypothalamic neurons. It promotes wakefulness, arousal, and energy expenditure via OX1R and OX2R receptors, and its deficiency (due to autoimmune destruction of orexin neurons) is the cause of narcolepsy with cataplexy. Orexin receptor antagonists (suvorexant, lemborexant) are approved for insomnia; orexin agonists are under development for narcolepsy.