Peptide Database

APLNR ligand · apelin-13

Apelin is an endogenous peptide that acts as the ligand for the APJ receptor (APLNR), a GPCR expressed throughout the cardiovascular system. It improves cardiac output and vascular tone through both positive inotropy and vasodilation, increases nitric oxide production, and reduces oxidative stress. Research focuses on heart failure, pulmonary arterial hypertension, and its potential to replace or complement established cardiac peptides.