Peptide Database

FPF 1070

Cerebrolysin is a mixture of neuropeptides and neurotrophic factors derived from porcine brain proteins. It mimics the actions of endogenous neurotrophic factors (NGF, BDNF, CNTF), promoting neuronal survival, synaptogenesis, and neuroplasticity. Approved in multiple countries for Alzheimer's disease, stroke recovery, and TBI, clinical trials show improvements in cognitive function, activities of daily living, and brain MRI outcomes.

Cortexin polypeptide complex

Cortexin is a polypeptide complex derived from the cerebral cortex of calves or pigs, containing a mixture of neuropeptides and neurotrophic factors. Approved in Russia for stroke, TBI, epilepsy, and cognitive disorders, it exhibits neuroprotective, nootropic, and anticonvulsant properties. Research supports improvements in cognitive function, reduced neurological deficit after stroke, and accelerated recovery from brain injury. It is conceptually similar to Cerebrolysin but derived from cortical tissue.

Byetta · Bydureon

Exenatide is a GLP-1 receptor agonist derived from exendin-4, a peptide found in Gila monster saliva. The first GLP-1 RA approved for type 2 diabetes, it established the GLP-1 drug class. Extended-release formulations (Bydureon) allow once-weekly dosing. Emerging research explores repurposing for Parkinson's disease, where small trials show motor improvement, and Alzheimer's disease neuroprotection.

N-phenylacetyl-L-prolylglycine ethyl ester · GVS-111

Noopept is a dipeptide-derived nootropic approved in Russia for cognitive disorders and memory impairment. It is hydrolyzed in vivo to release cycloprolylglycine, an endogenous neuropeptide. Research demonstrates neuroprotective, memory-enhancing, and anxiolytic effects, upregulation of BDNF and NGF in the hippocampus and cortex, and potential benefits in Alzheimer's disease models. It is significantly more potent than piracetam on a weight-for-weight basis.

MEHFPGP · Pro8-Gly9-Pro10-ACTH(4–10)

Semax is a synthetic heptapeptide analog of ACTH(4-7) developed in Russia, where it is approved for stroke, TBI, peptic ulcers, and cognitive enhancement. It upregulates BDNF and its receptor TrkB, promotes dopamine and serotonin turnover, and has demonstrated neuroprotective effects in ischemia models. Research highlights improvements in attention, memory, and recovery from neurological injury.

Thyrotropin-Releasing Hormone · Thyroliberin

TRH is a tripeptide (pGlu-His-Pro-NH2) produced in the hypothalamus that stimulates TSH and prolactin release from the anterior pituitary. Beyond thyroid regulation, TRH has direct CNS effects — it is alerting, antidepressant, neuroprotective, and anticonvulsant. Research explores TRH analogs (taltirelin, approved in Japan) for ALS, spinal cord injury, Alzheimer's disease, and treatment-resistant depression, avoiding thyroid side effects.