Peptide Database

Thyrotropin-Releasing Hormone · Thyroliberin

TRH is a tripeptide (pGlu-His-Pro-NH2) produced in the hypothalamus that stimulates TSH and prolactin release from the anterior pituitary. Beyond thyroid regulation, TRH has direct CNS effects — it is alerting, antidepressant, neuroprotective, and anticonvulsant. Research explores TRH analogs (taltirelin, approved in Japan) for ALS, spinal cord injury, Alzheimer's disease, and treatment-resistant depression, avoiding thyroid side effects.

UCN1 · Urocortin

Urocortin 1 (UCN1) is a 40-amino-acid member of the CRH peptide family that activates both CRHR1 and CRHR2 receptors. It has potent cardioprotective effects — improving cardiac contractility, reducing ischemia-reperfusion injury, and stimulating natriuresis — making it a significant heart failure research target. It also modulates anxiety and appetite centrally. Phase 2 trials for chronic heart failure showed improvements in cardiac function.

ADH · Antidiuretic Hormone

Vasopressin (AVP) is a 9-amino-acid neuropeptide produced in the hypothalamus and released by the posterior pituitary. It regulates water reabsorption via V2 receptors in renal collecting ducts and vasoconstriction via V1a receptors in blood vessels. Clinically used for diabetes insipidus, septic shock vasodilation, GI hemorrhage, and cardiac arrest. Extensive research also examines its roles in social bonding, memory, and stress responses.

Lys-Glu · KE dipeptide

Vilon is a synthetic dipeptide (Lys-Glu) developed at the St. Petersburg Institute of Bioregulation and Gerontology as a vascular cytoprotective peptide. Research demonstrates it reduces vascular endothelial cell aging, suppresses excessive collagen synthesis, and modulates the renin-angiotensin system. Long-term animal studies show improved vascular function and survival; it is often studied as part of peptide longevity protocols.

Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide with pleiotropic anti-inflammatory, bronchodilatory, and immunomodulatory effects mediated through VPAC1 and VPAC2 receptors. Research spans pulmonary arterial hypertension (inhaled VIP trials), inflammatory bowel disease, sepsis, Parkinson's disease, and CIRS (chronic inflammatory response syndrome). It suppresses Th1 cytokines and promotes Treg cell function.

Alpha-Melanocyte-Stimulating Hormone · α-Melanotropin

α-MSH is an endogenous 13-amino-acid peptide derived from POMC (pro-opiomelanocortin). It activates MC1R to stimulate melanin production in skin, MC4R to suppress appetite and regulate energy expenditure, and MC3R/MC1R to exert potent anti-inflammatory effects. It is the parent compound from which many synthetic melanocortin analogs (Melanotan I, II, PT-141, KPV) were derived and remains a cornerstone of melanocortin pharmacology research.