Peptide Database

Copper Peptide GHK · Glycyl-L-histidyl-L-lysine copper

GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Research demonstrates it stimulates collagen, elastin, and glycosaminoglycan synthesis, promotes wound healing, reduces inflammation, and activates protective antioxidant genes. Plasma levels decline with age, making it a significant anti-aging research target.

C₁₄H₂₄CuN₆O₄ · 340.84 Da (free ligand)

Pal-GHK · Matrixyl component

Palmitoyl Tripeptide-1 is a lipopeptide created by palmitoylating GHK (glycyl-histidyl-lysine), the same sequence as GHK-Cu without copper. The palmitoyl group enhances skin penetration, while the GHK sequence signals fibroblasts to upregulate collagen, elastin, and hyaluronic acid synthesis. It is a primary active ingredient in Matrixyl formulations and widely used in anti-aging cosmetics with clinical data supporting wrinkle reduction.