Peptide Database

MT-II · MT2

Melanotan II is a cyclic synthetic analog of α-MSH that non-selectively activates melanocortin receptors (MC1R–MC5R). It induces skin tanning (via MC1R), erectile function (via MC4R), and sexual arousal while also suppressing appetite. It was the precursor compound from which PT-141 was developed. Research continues despite regulatory concerns due to its broad receptor activity profile.

Bremelanotide · Vyleesi

PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist, FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women. Unlike PDE5 inhibitors, it acts centrally through MC3R and MC4R receptors in the hypothalamus to initiate sexual arousal, making it effective for psychological as well as physiological sexual dysfunction. Research also explores applications in male erectile dysfunction.

Alpha-Melanocyte-Stimulating Hormone · α-Melanotropin

α-MSH is an endogenous 13-amino-acid peptide derived from POMC (pro-opiomelanocortin). It activates MC1R to stimulate melanin production in skin, MC4R to suppress appetite and regulate energy expenditure, and MC3R/MC1R to exert potent anti-inflammatory effects. It is the parent compound from which many synthetic melanocortin analogs (Melanotan I, II, PT-141, KPV) were derived and remains a cornerstone of melanocortin pharmacology research.