Peptide Database

Small Humanin-Like Peptide 2

SHLP2 is a mitochondria-derived peptide (MDP) encoded in the 16S rRNA region of the mitochondrial genome, from the same region as humanin. It promotes mitochondrial biogenesis, reduces reactive oxygen species, and inhibits apoptosis in multiple cell types. Research shows it protects against age-related macular degeneration, reduces atherosclerosis risk, and is inversely correlated with type 2 diabetes and Parkinson's disease. Circulating SHLP2 declines with age.